Home Syllabus Syllabus for Pharmacy Officer- Gandaki Province PSC

Syllabus for Pharmacy Officer- Gandaki Province PSC

by Public Health Update

Course content

Section A- 20 Marks

  1. Development of Pharmacy and Drug Legislation in Nepal.
    1.1 Pharmaceutical development in Nepal.
    1.2 Pharmaceutical institution in Nepal.
    1.3 Drug legislation in Nepal.
    1.4 National Health Policy, National Drug Policy and their relation.
    1.5 Role and Responsibility of Nepal Pharmacy Council
  2. Pharmaceutical analysis
    2.1 Fundamental titrimetric analysis: Acid-base, Oxidation-reduction, Nonaqueous, Complexometric and potentiometric titrations; Ion selective electrodes.
    2.2 Spectroscopic methods of analysis, Absorption, Visible, IR, UV spectroscopy, Fluorimetry, Polarimetry, Atomic absorption and Emission spectroscopy.
    2.3 Gravimetric analytical methods and their applications.
    2.4 Separation techniques: Column, Paper, Thin layer, Ion exchange, Gel and Gas chromatography; High Performance Liquid Chromatography, High Performance Thin Layer Chromatography, Electrophoreses, and Mass Spectrometry
    2.5 Extraction and Importance of partition coefficient.
    2.6 Principles and application of microbiological assay of antibiotics and vitamins.
    2.7 Good Laboratory Practices, validation, references standards.
    2.8 Statistical analysis, sampling technique, analysis of variance.

    Section B- 20 Marks
  3. Pharmaceutics
    3.1. Prescription, proper handling of prescription, incompatibilities.
    3.2. Pharmaceutical dosage form: Fast, Immediate, Sustained/controlled release
    including novel drug delivery system. e.g. mucosal drug delivery systems.
    3.3. Manufacturing; Elements of Good Manufacturing Practice; WHO Certification Scheme on the Quality of Pharmaceutical Products Moving in International Commerce and its usefulness for quality assurance; packaging and stability of pharmaceutical products, costing of pharmaceutical formulation and prediction of maximum retail price.
    3.4. Pharmaceutical additives.
    3.5. Layout plan of pharmaceutical manufacturing plant including quality control, good manufacturing practice and safety measures in factories.
    3.6. Physical pharmacy; application of thermodynamics; rate and order of reaction; accelerated stability testing and shelf-life of drugs; pH; buffered and isotonic solution; solution of electrolytes; micromeritics; colloidal system; theology.
    3.7. Bioavailability and Bioequivalence studies.
  4. Microbiology and Immunology
    4.1 Scope of microbiology with special reference to pharmaceutical sciences, basic principles of sterility and pyrogen testing
    4.2 Microbial contamination test in pharmaceuticals, food, water and environment; classification of pathogenic microorganisms.
    4.3 Methodology of sterilization.
    4.4 Fundamental of Immunology, Testing of vaccines used in Extended Programme of Immunization.
    4.5 Basic Principles of Biotechnology

    Section C- 30 Marks
  1. Pharmacognosy
    5.1 Medicinal herbs of Nepal: Origin, distribution, cultivation, drying, pulverization, storage, and quality control.
    5.2 Plant analysis, types of plant constituents and physico-chemical standards.
    5.3 Plant based drugs in modern medicine.
    5.4 Extraction process and isolation of active ingredients, pilot plant processing.
  2. Pharmacology
    6.1 Mechanism and action of drugs, their safety, uses and mode of administration.
    6.2 Pharmacokinetics, pharmacodynamics and pharmacological evaluation of drugs.
    6.3 Poisoning: control and treatment.
    6.4 Adverse drug reaction and drug interactions.
  3. Medicinal Chemistry
    7.1 Characterization of organic compounds of pharmaceutical interest and specific reactions.
    7.2 Synthesis of important pharmaceuticals, their pharmacological action and antimicrobial activities.
    7.3 Structure Activity relationship of the drugs: Drug affecting Nervous system, NSAIDs, Cardiovascular drugs and Diuretics, Antimicrobial Drugs, Endocrinology and related drugs

    Section D- 30 Marks
  4. Drug Act & Pharmacopoeia
    8.1 Legislation
    8.1.1 DRUG ACT 2035
    8.1.2 Drug Registration Regulation 2038
    8.1.3 Drug Consultative Council and Drug Advisory Committee Regulation 2037
    8.1.4 Drug Investigation and Inspection Rules 2040
    8.1.5 Drug Standard Regulation 2043
    8.1.6 Ausadi Utpatad Sahita 2041
    8.1.7 Narcotic Drugs Control Act 2033
    8.2 Pharmacopoeia; Pharmacopoeial standards and their needs; importance and application of pharmacopoeial specification.
  5. Pharmaceutical Care and Drug Supply Management
    9.1 Comprehensive knowledge of clinical and hospital pharmacy; patient counseling and dosage adjustment in elderly, impaired liver and kidney; use of drug in neonates, children, pregnancy and lactation.
    9.2 Logistics management (selection, procurement, storage and distribution).
    9.3 Drug Financing Schemes (cost recovery, sharing and insurance).
    9.4 Concept of Essential Drugs, National Formulary, Hospital Formulary and Drug & Therapeutics Committee.
    9.5 Standard Treatment Schedules and rational use of drugs.
    9.6 Role of Pharmacist in hospital and community.
    9.7 Basic Principles of Pharmacoeconomics and Pharmaceutical Management.

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