The second round of national seroprevalence survey for SARS- CoV-2 in Nepal was conducted from 5th July to 23rd August 2021 to determine the current seroprevalence level in the general population. The objective was to estimate and understand the population-level immunity against SARS-CoV-2 and its change over time which are keys for understanding the spread of disease across the country. First round of seroprevalence survey for SARS-CoV-2 in Nepal was conducted from 9th October to 22nd October 2020.
This analysis was based on data from 13,439 study participants. The non-response rate was 1%. The overall weighted seroprevalence at national level was 70.7% (95% CI, 69.6- 72.0)-Table 01.
The second seroprevalence survey for COVID-19 was conducted during the period of 5th July to 23rd August 2021 using a sample size and sampling framework to estimate seroprevalence at provincial and national levels. Based on analysis of 13,439 samples collected, the estimated national seroprevalence at national level was 70.7%.
Province 2 showed the highest seroprevalence of 84.8% while the lowest seroprevalence of 62.9% was reported by Karnali province. The seroprevalence reported for male and female were comparable at 72.3% and 68.7% respectively. The age group 65-74 reported the highest seroprevalence of 79.4% while the 6-months to 4-year age group reported the lowest seroprevalence of 56.2%. The eco-regions terai, hills and mountains reported seroprevalences of 76.3%, 65.3%, and 60.5% respectively. All of which increased in comparison to the first serosurvey results. The seroprevalence reported for urban
and rural were comparable at 71.8% and 68.6% respectively. Fully vaccinated (including Janssen single dose) group showed the highest seroprevalence of 89.1% followed by the group that had one dose with seroprevalence of 82.0% and those who haven’t had vaccination with seroprevalence of 65.5%. The reported non-response rate was 1%.
Children had 35% less risk of getting seroconverted for SARS-CoV-2 compared to the working group. Males had a slightly higher and statistically significant risk of getting SARS-CoV-2infection with females. Acquiring SARS-CoV-2 was more likely in people who lived in terai and hill eco zones than mountain ecozones. The terai zone has approximately 2.5 times the risk than the mountain region. Living in an urban area also pose a 12% increased risk which is statistically significant compared to a rural area.