1.6K The reports (Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline and its companion publication, Antibacterial agents in preclinical development) also found that research and development for antibiotics is primarily driven by small- or medium-sized enterprises with large pharmaceutical companies continuing to exit the field.
Lack of new antibiotics threatens global efforts to contain drug-resistant infections
Declining private investment and lack of innovation in the development of new antibiotics are undermining efforts to combat drug-resistant infections, says the World Health Organization (WHO).
Two new reports reveal a weak pipeline for antibiotic agents. The 60 products in development (50 antibiotics and 10 biologics) bring little benefit over existing treatments and very few target the most critical resistant bacteria (Gram-negative bacteria).
While pre-clinical candidates (those in early-stage testing) are more innovative, it will take years before they reach patients.
“Never has the threat of antimicrobial resistance been more immediate and the need for solutions more urgent,” says Dr Tedros Adhanom Ghebreyesus, Director-General of WHO. “Numerous initiatives are underway to reduce resistance, but we also need countries and the pharmaceutical industry to step up and contribute with sustainable funding and innovative new medicines.”
News release Geneva
Recommended Readings
- WHO lists top 10 threats to global health in 2019
- World Health Organization Model List of Essential Medicines (21st List 2019)
- WHO priority pathogens list for research and development (R&D) of new antibiotics
- WHO announces updates on new molecular assays for the diagnosis of tuberculosis and drug resistance
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