Home Communicable Diseases Clinical Handbook of TB management Protocols 2024

Overview

The Clinical Handbook of TB management Protocols 2024 offers an overview of tuberculosis and provides insights into national diagnostic and treatment protocols, highlighting recent advancements, especially in managing drug-resistant TB (DR-TB) with shorter, all-oral treatment regimens. This handbook includes guides on the following topics.

Screening and Diagnosis

  • Methods of screening and diagnosis
  • Suggested screening strategies for presumptive TB cases
  • WHO recommended tools for TB screening
  • Laboratory tests of tuberculosis
  • Methods of obtaining a respiratory specimen
  • Diagnostic algorithm and treatment initiation for new presumptive TB patients
  • Diagnostic algorithm and treatment initiation for previously treated TB patients and interpretation of X-pert MTB/RIF/Ultra results
  • Interpretation of X-pert MTB/RIF and/or X-pert MTB/RIF/Ultra results
  • Interpretation of drug susceptibility test by LPA Result and treatment decision
  • Diagnosis of extrapulmonary TB in adults
  • Identifying presumptive TB in children
  • Critical signs requiring urgent hospital referral
  • Diagnostic algorithm of TB in Children (<15 years of age)
  • Screening and management of TB in Severe Acute Malnutrition (SAM) children
  • Systematic Screening for the Diagnosis of active pulmonary TB disease among PLHIV, Diabetes and other immune suppressant co-morbid conditions

Drug susceptible (DS) TB treatment and management

  • DS TB treatment and anti-TB drug regimens
  • Summary of extrapulmonary TB (EPTB) treatment
  • Dosing for DS TB treatment (Adults and Children)
  • Monitoring and follow up management of DS TB
  • Flow Chart for management and follow up of Pulmonary Bacteriologically Confirmed (PBC) TB patients
  • Management of patients who interrupted treatment

Drug Resistant (DR) TB Treatment and Management

  • Type of drug resistant (DR) TB
  • Treatment of isoniazid resistant TB (Hr-TB)
  • Decision tree for the diagnosis and treatment of MDR/RR TB
  • Treatment of multi-drug/rifampicin resistant (MDR/RR) TB
  • Weight based dosing of medicines used in multidrug resistant TB regimens, adults, and children
  • Follow up and monitoring of DR TB patients

Monitoring and Management of adverse events

  • Side effects of first line TB medicines and management
  • Side effects of second line TB medicines
  • Approach to hepatotoxicity caused by first-line anti- tuberculous drugs in adult
  • Dose adjustment in renal impairment

TB treatment in special circumstances

  • TB in people with HIV infection
  • TB in pregnancy and breast feeding
  • TB and diabetes mellitus (DM)
  • TB and tobacco Use

TB Infection Control and Prevention

  • TB Infection Control
  • TB Preventive Treatment (TPT)

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