Overview
The Clinical Handbook of TB management Protocols 2024 offers an overview of tuberculosis and provides insights into national diagnostic and treatment protocols, highlighting recent advancements, especially in managing drug-resistant TB (DR-TB) with shorter, all-oral treatment regimens. This handbook includes guides on the following topics.
Screening and Diagnosis
- Methods of screening and diagnosis
- Suggested screening strategies for presumptive TB cases
- WHO recommended tools for TB screening
- Laboratory tests of tuberculosis
- Methods of obtaining a respiratory specimen
- Diagnostic algorithm and treatment initiation for new presumptive TB patients
- Diagnostic algorithm and treatment initiation for previously treated TB patients and interpretation of X-pert MTB/RIF/Ultra results
- Interpretation of X-pert MTB/RIF and/or X-pert MTB/RIF/Ultra results
- Interpretation of drug susceptibility test by LPA Result and treatment decision
- Diagnosis of extrapulmonary TB in adults
- Identifying presumptive TB in children
- Critical signs requiring urgent hospital referral
- Diagnostic algorithm of TB in Children (<15 years of age)
- Screening and management of TB in Severe Acute Malnutrition (SAM) children
- Systematic Screening for the Diagnosis of active pulmonary TB disease among PLHIV, Diabetes and other immune suppressant co-morbid conditions
Drug susceptible (DS) TB treatment and management
- DS TB treatment and anti-TB drug regimens
- Summary of extrapulmonary TB (EPTB) treatment
- Dosing for DS TB treatment (Adults and Children)
- Monitoring and follow up management of DS TB
- Flow Chart for management and follow up of Pulmonary Bacteriologically Confirmed (PBC) TB patients
- Management of patients who interrupted treatment
Drug Resistant (DR) TB Treatment and Management
- Type of drug resistant (DR) TB
- Treatment of isoniazid resistant TB (Hr-TB)
- Decision tree for the diagnosis and treatment of MDR/RR TB
- Treatment of multi-drug/rifampicin resistant (MDR/RR) TB
- Weight based dosing of medicines used in multidrug resistant TB regimens, adults, and children
- Follow up and monitoring of DR TB patients
Monitoring and Management of adverse events
- Side effects of first line TB medicines and management
- Side effects of second line TB medicines
- Approach to hepatotoxicity caused by first-line anti- tuberculous drugs in adult
- Dose adjustment in renal impairment
TB treatment in special circumstances
- TB in people with HIV infection
- TB in pregnancy and breast feeding
- TB and diabetes mellitus (DM)
- TB and tobacco Use
TB Infection Control and Prevention
- TB Infection Control
- TB Preventive Treatment (TPT)
Recommended readings
- National TB Preventive Treatment Protocol 2024
- National Guide for use of digital x-ray with AI in camp settings
- National Tuberculosis Programme Annual Report 2018
- National Tuberculosis Program Update in Nepal #WorldTBDay #EndTB
- National TB Prevalence Survey, 2018-19 Key findings
- World Tuberculosis Day 2020! It’s time to End TB!
- National Guideline on Drug Resistant TB Management 2019, Nepal
- National Tuberculosis Management Guideline 2019, Nepal
- Global Tuberculosis Report 2019: Latest status of the tuberculosis epidemic
- National TB Prevalence Survey, 2018-19 Key findings
- New WHO recommendations to prevent tuberculosis aim to save millions of lives
- World Health Organization (WHO) Information Note Tuberculosis and COVID-19
- World Tuberculosis Day 2020! It’s time to End TB!
- People-centred framework for tuberculosis programme planning and prioritization, User guide
- Global Tuberculosis Report 2019: Latest status of the tuberculosis epidemic
- Dissemination of Findings and Recommendations of Joint External Monitoring Mission(JEMM) of Nepal National Tuberculosis Program
- National Tuberculosis Programme Annual Report 2018
- National Strategic Plan for Tuberculosis Prevention, Care and Control 2016 – 2021
- NTP, Nepal: New TB Treatment Algorithm & Regimen (Updated)
- WHO announces landmark changes in MDR-TB treatment regimens
- TB Vaccine results announce a promising step towards ending the emergency
- 7 million people receive record levels of lifesaving TB treatment but 3 million still miss out
Related reports
- Global Tuberculosis Report 2024
- Global tuberculosis report 2023
- Global Tuberculosis Report 2022
- Global Tuberculosis Report 2021
- Global Tuberculosis Report 2020
- National Strategic Plan to End Tuberculosis in Nepal
- Global Tuberculosis Report 2019: Latest status of the tuberculosis epidemic
- Global Tuberculosis Report 2018
- WHO Global Tuberculosis report 2015
- Global tuberculosis report 2014: Improved data reveals higher global burden of tuberculosis